Note the difference between "Regional" (which is like "World/English/Regional" -- that is, contains only sites with English content) and "World" (which contains sites in languages other than English, whether Regionally-relevant or not.)
By the "general section", I think you mean the "English-language categories". If that's correct, treat (for instance) "Business" categories as if they were called "World/English/Business".
If a site is truly multilingual (as opposed to babelfish-enabled) you may (and please do!) submit to one appropriate category in each Language.
In some languages, some sites may be eligible for both a Topical and a Regional listing. This is more likely for languages like English/French/Spanish that are spoken in multiple continents or countries; less likely in languages like Romanian/Japanese/Danish that are spoken almost exclusively in one region (thus, "World/Japanese/Regional/Japan/Business" would be nearly equivalent to "World/Japanese/Business". For languages somewhere in the middle, like Dutch, better ask specifically.